REIGN

REIGN Lab

REsearch in Integrative GeNomics of hypoxia

Oxygen sensing across biological scalesA single continuous scene travelling from the atmosphere and a human figure, through organs, tissue, a cell and its nucleus, to chromatin and DNA, then back out to the whole-body response.O₂O₂O₂O₂O₂O₂

Hypoxia Biology · An interactive scale study

WHEN OXYGEN FALLS

One continuous journey from the air around us to the molecules that rewrite gene expression — and back out to the whole organism.

Drag to travel · select an annotation to inspect

The full scientific referenceExplore hypoxia in detail

Research

01

High-altitude omics

High-altitude environments serve as a natural laboratory for studying physiological and pathophysiological responses to hypobaric hypoxia. The lab uses genomics, transcriptomics, targeted proteomics, and global DNA methylation analysis to deepen understanding of hypobaric hypoxia in health and disease.

Multi-omicsHypoxiaHigh altitude
Scientific chord diagram representing integrative multi-omics relationships
Integrative Multi-Omics Approaches to Map Adaptive and Maladaptive Biological Signatures at High Altitude

People

Portrait of Dr. Aastha Mishra, Principal Investigator at REIGN Labs

Dr. Aastha Mishra

Principal Investigator

Senior Scientist at the CSIR-Institute of Genomics and Integrative Biology (IGIB), New Delhi. Her research spans integrative genomics of hypoxia, cardiovascular genetics, and non-invasive liquid biopsy approaches.

Meet the Team

Publications

Selected scientific contributions from the laboratory: peer-reviewed research articles, book chapters, and conference abstracts.

Read all Publications

News & Events

A record of laboratory milestones: publications, symposia, awards, and members joining REIGN Labs.

2026Recent Developments

  • Congratulations for NABL accreditation to Dr Aastha Mishra, Faculty-in-charge, Phenome India Biobank Facility

  • Congratulations to Dr Aastha Mishra for being awarded the ICMR Intermediate Grant titled “Clinical Outcomes, Founder Mutation Analysis, and Functional Electrophysiology in Long QT and Brugada Syndromes: Extending the Comprehensive Evaluation of Inherited Cardiac Channelopathy Cohort.”

  • Congratulations to Dr Aastha Mishra on being awarded the ICMR Small Grant for the project titled “Comprehensive Genomic Investigation of Cardiac Channelopathies: Going Beyond Pathogenic Exomes.”

  • Congratulations to Kanika Singh on being awarded the ANRF International Travel Support Grant to attend and present her research at the European Respiratory Society (ERS) Congress 2026

  • Congratulations to Raushni Choudhary on receiving the Travel Award for PVRI 2027, Bangkok.

  • Congratulations to Shraddha Handa on receiving the Best Paper Award for oral presentation at the ISHR–India Section Meeting 2026 in the Basic Sciences Category.

  • Congratulations to Mohit Khadia on securing a grant to attend the 2026 International Statistical Genetics Workshop for Human Complex Traits.

  • Congratulations to Kaushlendra Mishra on qualifying CSIR-NET JRF (June 2026) with an All India Rank (AIR) of 74.

  • Welcome to the lab, Rani Kumari, as part of our new PhD batch.

  • Welcome to the lab, Pooja Jaglan, as part of our new PhD batch.

2025Lab Highlights

  • Congratulations to our lab for publications in Pulmonary Circulation and Bioscience Reports

  • Congratulations to Shraddha Handa on being awarded SRF!

  • Congratulations to Shraddha Handa on securing 2nd Position under the Clinical Sciences Category at the Cardiovascular Research Convergence 2025, and being awarded the Prof. Balram Bhargava Award for her oral presentation

2024Lab Growth

  • Congratulations to our lab for publications in American Journal of Physiology and Clinical Science!

  • LEH SYMPOSIUM on high-altitude research was successfully conducted.

  • Congratulations to Manzoor Ali for being awarded First Prize in Poster Presentation at the 7th International Leh Symposium 2024.

  • Congratulations to Shraddha Handa on securing 3rd Position in the Best Poster Presentation Category at the 7th International Leh Symposium 2024.

  • Congratulations to Manzoor Ali for presenting a poster at the PVRI 2024 Annual Congress, held in London.

2023Lab Growth

  • Welcome Krishna Kumar, Shraddha Handa & Arun Paulose to our research team!

  • Congratulations to Manzoor Ali and Swati Kumari on being awarded SRF!

2022New Members

  • Welcome Kanika Singh and Swati Kumari to the REIGN lab!

2021Lab Launch

  • Welcome Manzoor Ali and Raushni Choudhary as founding members of REIGN lab!

Funding & Collaboration

Supported by

  • Council of Scientific and Industrial Research (CSIR)

    Council of Scientific and Industrial Research (CSIR)

  • Indian Council of Medical Research (ICMR)

    Indian Council of Medical Research (ICMR)

  • Science and Engineering Research Board (SERB)

    Science and Engineering Research Board (SERB)

Our Community

Hypoxia-related studies are the center of our research, and both male and female researchers contribute to the laboratory.

We respect and honor the diversity in our community that includes but is not limited to race, ethnicity, national origin, gender identity, gender expression, sexual orientation, age, disability, socio-economic status, class, and religion.

Researchers with a background in Genomics, Bioinformatics, Computational Biology, Machine Learning, or Biostatistics who are seeking research opportunities are encouraged to contact Dr. Aastha Mishra.